Associate Scientist I/II, DNA-Encoded Libraries - Molecular Biology

High-Throughput Chemistry · South San Francisco, California
Department High-Throughput Chemistry
Employment Type Full-Time

The Opportunity

An experienced molecular biologist or molecular biologist-in-training is sought. Expertise in many types of nucleic acid handling is required: PCR, restriction digestion, gel electrophoresis etc. Duties will include acquiring accurate and precise data to build data sets at the intersection of chemistry and biology.Machine learning integrated with chemistry/biology at scale lies at the core of insitro’s approach to rethinking drug discovery and development. As our Associate Scientist you will be a key member of the High-Throughput Chemistry team working on the synthesis of DNA-Encoded chemical Libraries (DELs) and subsequently screening these DELs using the company’s proprietary nDexer platform for drug discovery. You will be a member of cross-functional teams, comprising machine learning engineers, life scientists, automation engineers and data scientists. You will demonstrate world-class research skills and experience in developing and using cutting-edge molecular biology methods. You will hone your interpersonal skills, and build a strong collaborative work ethic, as well as the ability to adapt to changing needs, and the capacity to multitask to meet key goals. Exceptional attention to detail and communication skills are essential to success in this position. 

Specifically, you will:

  • Participate in DNA-Encoded Library synthesis as a molecular biologist using a broad array of molecular biological techniques
  • Process DNA samples for NGS sequencing 
  • Contribute to the design of new libraries
  • Participate in the design, development, optimization, validation and integration of automation processes for high-throughput parallel synthesis and analysis
  • Operate and maintain automation systems
  • Design and execute experiments
  • Analyze experimental results
  • Present results to cross-functional teams

You will be joining the founding team of a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. Much can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with an exceptionally talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

About You

  • B.S./M.S. in molecular biology, chemical/bioengineering or equivalent with 1-3 years of relevant experience in the pharmaceutical/biotech industry
  • Hands-on experience with DEL synthesis, or molecular biology techniques including but not limited to PCR, qPCR, transcription, reverse transcription, gel electrophoresis in a high-throughput setting
  • Meticulous about documenting experimental and analytical work with remarkable attention to detail in all aspects of the job
  • Adept in handling liquid dispensers, plate readers and similar lab equipment 
  • Experience in buffer and media preparation
  • Strong data-entry and analysis skills. Experience in Google Suite, Confluence, and LIMS system is preferred
  • Ability to translate broad directives into action with minimal supervision
  • Excellent oral and written communication skills
  • Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions in a fast-paced, goal-oriented team environment
  • A desire to transform drug discovery and help patients 

Nice to Have

  • Experience in sequencing and bioinformatics (DNA sequences, RNAseq etc.)
  • Experience in organic chemistry synthesis, solid-phase peptide synthesis, oligo synthesis or other chemical synthesis techniques
  • Experience with automation/liquid handling 
  • A demonstrated expertise in scientific programming (e.g., Python, Java, C++, SVL) with practical application of these skills is a strong plus

Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Commuter benefits
  • Paid parental leave

About insitro

insitro is a data-driven drug discovery and development company using machine learning and high-throughput biology to transform the way that drugs are discovered and delivered to patients. The company is applying state-of-the-art technologies from bioengineering to create massive data sets that enable the power of modern machine learning methods to be brought to bear on key bottlenecks in pharmaceutical R&D. The resulting predictive models are used to accelerate target selection, to design and develop effective therapeutics, and to inform clinical strategy. insitro was launched in 2018 with a Series A of $100M funded by top investors including a16z, Arch Venture Partners, Foresite Capital, GV, and Third Rock Ventures.

The company has announced collaborations with Gilead Sciences in the area of NASH (2019) and Bristol Myers Squibb in the area of ALS (2020) and, in mid 2020, completed a Series B financing of $143M including current investors and new investors Canada Pension Plan Investment Board (CPP Investments), T. Rowe Price, BlackRock, Casdin Capital and other leading investors. The company is located in South San Francisco, CA. For more information about insitro, please visit the company’s website at 

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  • Location
    South San Francisco, California
  • Department
    High-Throughput Chemistry
  • Employment Type