Head of Translational Genetics

Translational Science · South San Francisco, California
Department Translational Science
Employment Type Full-Time

The Opportunity

The heart of insitro’s strategy is the combination of novel, cutting edge methods in machine learning, high-throughput biology and disease modeling that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of highly talented leaders in translational science who want to make a difference to this important problem. In this role, you will play a key part in building our Translational Genetics effort as a member of insitro’s Translational Science department. As the Translational Genetics lead, you will be responsible for the integration of human genetics data with multidimensional phenotypic and OMICS data to identify and validate drug targets in our core therapeutic areas on cross-functional teams. 

You will oversee and guide the use of cutting edge statistical approaches and workflows to analyze large-scale human cohorts with genetic and multi-dimensional, multi-modality phenotypic data. These data sets will be obtained from public sources, as well as private datasets generated in-house and obtained through our collaborations. You will use genetic association and other statistical genetics techniques that involve integration of genetic, genomic and clinical data to (i) guide in vitro disease model development, (ii) select candidate drug targets; and (ii) support drug development programs. 

Your primary duties will be to:

  • Contribute to formulating insitro’s long-term therapeutic strategy in neurosciences and fibrosis indications; 
  • Guide and oversee the use of cutting edge machine learning models and statistical genetics analyses in large-scale genetic human cohorts with rich and multi-modal phenotypic data in order to advance our Therapeutic Programs and guide in vitro disease model development; 
  • Collaborate with a multidisciplinary team consisting of human genetics scientists, statistical geneticists and other team members to design, execute and interpret genetics studies in neuroscience and fibrosis indications;
  • Generate, summarize, contribute to the writing of scientific reports and present results in internal and external meetings to a variety of audiences;
  • Contribute to our partnered diseases programs, collaborating with relevant counterparts at our collaborator company to ensure timely delivery of the program goals; 
  • Lead efforts to relentlessly follow up on novel candidate targets with the goal of producing viable therapeutic interventions and identification of genetically-defined patient populations that might benefit from them.

You will be joining as the founding team of a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

About You

  • MD and/or PhD in technical field (Statistical Genetics, Data Sciences, Biomedicine, etc.) or equivalent practical experience
  • 8+ years of experience in a role involving translational science or drug development with relevant industry experience
  • A track record of using unbiased, data-driven approaches for scientific research 
  • A strong scientific track record in translational genetics or a related field
  • Enthusiasm for using clinical data and genetics to inform the development of cell-based systems as disease models
  • A record of innovation, exemplified by generating ideas, launching and advancing projects
  • Demonstrated ability to integrate human genetics with diverse and multi-dimensional datasets
  • Demonstrated ability to execute human genetics studies delivering novel genetic findings and medically relevant gene discoveries in a team-based environment
  • Familiarity and experience with the applications of statistical genetics to gain medically-actionable insights, including conditional analyses, fine-mapping, QTL analyses and Mendelian randomization
  • Ability to analyze complex loci, use gene-specific and genome-wide polygenic scores, or perform genetic studies that simulate randomized controlled trials
  • Interest in understanding the genetic basis and causes of neurological and fibrotic diseases and translating this knowledge into therapeutic insights (an outstanding candidate will have previous experience in these therapeutic areas)
  • Track record of building and leading teams, including goal setting
  • Ability to operate within a fast-moving, startup environment
  • Highly collaborative, team-oriented, and an effective communicator
  • Passion for making a difference in the world

Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Commuter benefits
  • Paid parental leave

About insitro

insitro is a data-driven drug discovery and development company using machine learning and high-throughput biology to transform the way that drugs are discovered and delivered to patients. The company is applying state-of-the-art technologies from bioengineering to create massive data sets that enable the power of modern machine learning methods to be brought to bear on key bottlenecks in pharmaceutical R&D. The resulting predictive models are used to accelerate target selection, to design and develop effective therapeutics, and to inform clinical strategy. insitro was launched in 2018 with a Series A of $100M funded by top investors including a16z, Arch Venture Partners, Foresite Capital, GV, and Third Rock Ventures.

The company has announced collaborations with Gilead Sciences in the area of NASH (2019) and Bristol Myers Squibb in the area of ALS (2020) and, in mid 2020, completed a Series B financing of $143M including current investors and new investors Canada Pension Plan Investment Board (CPP Investments), T. Rowe Price, BlackRock, Casdin Capital and other leading investors. The company is located in South San Francisco, CA. For more information about insitro, please visit the company’s website at www.insitro.com 

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  • Location
    South San Francisco, California
  • Department
    Translational Science
  • Employment Type