(Associate) Scientist, Liver Phenotypic Assay Group

Translational Science · South San Francisco, California
Department Translational Science
Employment Type Full-Time

The Opportunity

The heart of insitro’s strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together a team of life scientists with expertise in cellular and biochemical assays. In this role, you will lead projects focused on identifying and validating intermediate phenotypes of disease processes. In collaboration with the Functional Genomics, Disease Modelling and Process Engineering groups, you will develop liver disease phenotypic assays to enable screening of chemical libraries and genetically modified cells. There will be the opportunity for career development and over time taking on the responsibility of target prosecution and the establishment of validated biomarker assays that can be used for IND applications and/or clinical development programs.


Your primary duties will be to: 

  • work on a team prosecuting target biologies in liver therapeutic areas, including lipid metabolism, cell death, inflammation and fibrosis; 
  • prototype, optimize and qualify in vitro cellular and molecular assays that model disease processes; 
  • partner with data scientists and machine learning experts to establish datasets that permit identification of latent features in high-content assays that can be used to predict results obtained from bespoke disease-specific assays; 
  • design, execute and analyze life-science experiments and present findings to project teams; 
  • work with automation and bioinformatics experts to implement robust and high throughput sample preparation, high content screening and data analysis workflows.


You will be joining a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

 

About You

  • B.S., M.S. or recent PhD in technical field (molecular biology, cellular biology, etc.) or equivalent practical experience
  • Broad experience with state-of-the-art cellular and molecular assays
  • Experience culturing different cell types (primary, IPSC-derived and immortalized)
  • Work experience in a role involving biomarker research or drug target identification desired 
  • Experience building or desire to collaborate with data scientists or computational biologists, engineers and experimental biologists
  • Experience working as part of a high-performance team, including goal setting, and contributing to a culture of effective, high-quality methods development and reducing those methods to a practical implementation
  • Familiarity with automated or semi-automated instrumentation, while not required, would be advantageous, 
  • Other criteria will include: a record of publications in a relevant scientific discipline; excellent teamwork, communication, time management and organization skills
  • Passion for making a difference in the world


Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Commuter benefits
  • Paid parental leave

 

About insitro

insitro is a data-driven drug discovery and development company using machine learning and high-throughput biology to transform the way that drugs are discovered and delivered to patients. The company is applying state-of-the-art technologies from bioengineering to create massive data sets that enable the power of modern machine learning methods to be brought to bear on key bottlenecks in pharmaceutical R&D. The resulting predictive models are used to accelerate target selection, to design and develop effective therapeutics, and to inform clinical strategy. insitro was launched in 2018 with a Series A of $100M funded by top investors including a16z, Arch Venture Partners, Foresite Capital, GV, and Third Rock Ventures. In 2019 the company announced a collaboration with Gilead Sciences in the area of NASH and, in mid 2020, announced a Series B financing of $143M including current investors and new investors Canada Pension Plan Investment Board (CPP Investments), T. Rowe Price, BlackRock, Casdin Capital and other leading investors. The company is located in South San Francisco, CA. For more information about insitro, please visit the company’s website at  www.insitro.com.

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  • Location
    South San Francisco, California
  • Department
    Translational Science
  • Employment Type
    Full-Time