Machine learning, integrated with data generation at scale, lies at the core of insitro’s approach to rethinking drug discovery and development. As Head of Oligonucleotide Therapeutics Design you will lead our oligonucleotide medicinal chemistry efforts, and in the process, help us transform how oligonucleotide drugs are designed, through the use of powerful predictive models, relating molecular structure to drug property, built through machine learning. You will couple these models with new ways of exploring and interrogating oligonucleotide molecular property space, achieving significant advances in the speed, scale and success rates of hit discovery and lead optimization. You will drive our oligonucleotide therapeutic design across a portfolio of therapeutic programs, delivering a stream of outstanding clinical candidates, and helping advance these into the clinic.
You will work closely with world-class machine learning, data engineering, high throughput biology and translational science teams to grow our oligonucleotide drug design capabilities and scale our therapeutic portfolio. You will partner with therapeutic teams to design and execute research project plans which reflect insitro’s data science-led philosophy for oligonucleotide drug discovery. You will have demonstrated your ability to work in a highly cross-disciplinary, fast-moving and fluid environment, and will draw upon extensive experience driving oligonucleotide drug discovery projects forward. You will possess strong interpersonal and leadership skills, an ability to lead cross-functionally, a strong collaborative work ethic, ability to adapt to changing needs, and the capacity to multitask to meet key goals. Strong communication and presentation skills are essential to success in this position. Specifically, you will:
You will be joining a biotech startup that has long-term stability due to significant funding, but where there is still considerable opportunity to add distinctive new capabiliies. Much can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with an exceptionally talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
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Benefits at insitro
insitro is a drug discovery and development company using machine learning and data generation at scale to transform the way that drugs are discovered and delivered to patients. We rely on human genetic cohorts, human-derived cellular disease models, and high-throughput biology and chemistry to identify coherent patient segments, actionable therapeutic targets, and new or existing chemical matter. The goal is to deliver predictive insights to improve the probability of success and reduce the number of costly dead ends along the R&D journey. The company has established enabling collaborations with Gilead in NASH and Bristol Myers Squibb in ALS and is building a pipeline of wholly owned and partnered medicines leveraging its unique insights on patient biomarkers, targets, and molecules. insitro is located in South San Francisco, CA and has raised over $600M from top tech, biotech, and crossover investors since formation in 2018. For more information on insitro, please visit the company’s website at www.insitro.com.
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