(Senior) ML Engineer - Clinical Data

Computing · South San Francisco, California
Department Computing
Employment Type Full-Time
Minimum Experience Mid-level

The Opportunity

Key to insitro’s approach to rethinking drug development is leveraging disease models, genetics, and clinical datasets to link in vitro and cellular phenotypes with patient outcomes.

As a machine learning engineer with expertise in clinical data analysis, you will develop cutting edge ML approaches to analyze and integrate large-scale multi-modal phenotypic datasets, including medical imaging modalities, physiological monitoring, and longitudinal clinical data. You will work with clinical data from randomized clinical trials, large human cohorts such as electronic health records, and other sources. You will also work closely with a cross-functional team of life scientists, statistical geneticists, bioengineers and machine learning scientists to integrate human level data with our high-throughput in-house in vitro genomic and phenotypic data to identify therapeutic targets and develop drugs that have high efficacy and low toxicity.


You will be joining as the founding team of a biotech startup that has long-term stability due to significant funding, but yet is in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!


About You

  • Ph.D. in machine learning, computer science, computational biology or a related discipline, or equivalent practical experience (e.g., a Masters degree plus 2 years in relevant industry experience);
  • Demonstrated ability to use and develop cutting edge methods for analyzing imaging data;
  • Extensive hands on experience working with biomedical or biophysical imaging modalities;
  • Demonstrated ability to rigorously deal with confounders and complexities in human clinical data;
  • Experience using modern deep learning frameworks (TensorFlow, PyTorch, Keras, etc);
  • Proficiency in Python and working with large-scale image datasets ;
  • Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions;
  • Passion for making a difference in the world.


Nice to Have

  • Experience working with genetic analyses (e.g., GWAS, rare variant analysis, etc) and / or genomic data from different modalities (DNA sequencing, RNA-seq, proteomics, DNA accessibility assays, etc.);
  • Experience developing models for diverse computer vision tasks (e.g. segmentation, recognition, classification, domain adaptation);
  • Familiarity with cloud computing services (e.g., AWS or GCP) and workflow management tools or batch scheduling systems (e.g. SLURM);
  • Proficiency in Linux environment (including shell/Bash scripting), experience with database languages (e.g., SQL) and experience with version control practices and tools (e.g., Git)


Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Complementary onsite barista and snacks 
  • Commuter benefits
  • Paid parental leave


About insitro

insitro is a drug discovery and development company using machine learning and data generation at scale to transform the way that drugs are discovered and delivered to patients. We rely on human genetic cohorts, human-derived cellular disease models, and high-throughput biology and chemistry to identify coherent patient segments, actionable therapeutic targets, and new or existing chemical matter. The goal is to deliver predictive insights to improve the probability of success and reduce the number of costly dead ends along the R&D journey. The company has established enabling collaborations with Gilead in NASH and Bristol Myers Squibb in ALS and is building a pipeline of wholly owned and partnered medicines leveraging its unique insights on patient biomarkers, targets, and molecules. insitro is located in South San Francisco, CA and has raised over $600M from top tech, biotech, and crossover investors since formation in 2018. For more information on insitro, please visit the company’s website at www.insitro.com.

Thank You

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  • Location
    South San Francisco, California
  • Department
    Computing
  • Employment Type
    Full-Time
  • Minimum Experience
    Mid-level