Principal or Senior Scientist, Disease Modeling

High-Throughput Biology · South San Francisco, California
Department High-Throughput Biology
Employment Type Full-Time

The Opportunity

The heart of insitro’s strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology to address key bottlenecks in the drug development pipeline. In alignment with this strategy, the disease modeling group is building up a large repertoire of scaleable cellular models for multiple disease indications.

As a Senior or Principal Scientist in the Disease Modeling group, working as an individual contributor and a leader of a small research group you will help to establish robust, high throughput iPSC differentiation techniques to produce critical cell-types to model various diseases in vitro. You will be involved with both the incorporation and scale-up of established protocols, as well as the invention of novel differentiation methods using insitro’s data-driven functional genomics approaches. You will work closely with the Process Engineering, Translational Sciences and Data Sciences teams to build scalable in vitro disease models. 

We are looking for motivated and talented candidates who are interested in being part of a unique, cross-disciplinary team of biologists, bioengineers, machine learners and data scientists who want to make a difference. You will be joining as the founding team of a biotech startup that has long-term stability due to significant funding yet is very much in forming mode, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us and help make a difference to patients!

About You

  • PhD in biological science, bioengineering or relevant disciplines, or equivalent experience
  • 5+ years of relevant work experience, in academia or in industry
  • Experience with leading research teams and mentoring junior researchers
  • Strong experience with mammalian cell culture and in vitro assay development required
  • Experience with pluripotent stem cell culture and differentiation methods 
  • Deep understanding of liver and/or neurodegenerative diseases 
  • Excellent lab practice and organization required
  • Experience in characterizing mammalian cell cultures via FACS, single cell transcriptomics, or high-content imaging
  • Excellent oral and written communication skills
  • Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions in a fast-paced, goal-oriented team environment

Nice to Have

  • Both 2D and 3D cell culture and assay experience
  • Strong microscopy skills, including immunohistochemistry, 3D imaging, in situ hybridization, live cell imaging, and/or high content imaging
  • Familiarity with high throughput screening
  • Experience with automated liquid handler systems for cell culture (i.e., Bravo, Tecan, Hamilton)

Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Commuter benefits
  • Paid parental leave

About insitro

insitro is a data-driven drug discovery and development company using machine learning and data generation at scale to transform the way that drugs are discovered and delivered to patients. insitro’s approach focuses on the development of predictive machine learning models to be brought to bear on key bottlenecks in pharmaceutical R&D. The company has established enabling collaborations with Gilead in NASH and Bristol Myers Squibb in ALS. insitro is located in South San Francisco, CA and has been supported by top tech, biotech, and crossover investors since formation in 2018. For more information on insitro, please visit the company’s website at

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  • Location
    South San Francisco, California
  • Department
    High-Throughput Biology
  • Employment Type