Scientist I/II, Microfluidics and Capillary Electrophoresis

High-Throughput Chemistry · South San Francisco, California
Department High-Throughput Chemistry
Employment Type Full-Time

The Opportunity

Machine learning integrated with chemistry/biology at scale lies at the core of insitro’s approach to rethinking drug discovery and development. To accomplish that, we are putting together a team of life scientists with expertise in the design, use, and application of microfluidic devices and microfluidic electrophoresis. Responsibilities in this role will include acquiring, designing, and/or building devices needed for performing high-resolution analyses and separations of very complex sample mixtures, and / or analytes that are exceptionally hard to separate. You will also acquire accurate and precise data to build data sets with many different proteins and biomolecules, and working as part of a cross-functional team to automate collection of biological and chemical data for drug discovery. You will work in concert with numerous cross-functional teams, comprising machine learning engineers, life scientists, automation engineers and data scientists. You will demonstrate world-class research skills and experience in developing and using cutting-edge molecular biology methods. You will hone your interpersonal skills, and build a strong collaborative work ethic, as well as the ability to adapt to changing needs, and the capacity to multitask to meet key goals. Exceptional attention to detail and communication skills are essential to success in this position. 

Specifically, you will:

  • Design and build microfluidic devices to effect analytical separations of biomacromolecules and small molecules
  • Source and use commercially available devices for performing such separations
  • Aid in the development of biochemical assays 
  • Aid in the development of automated processes for analytical and preparative separations 

You will be joining the founding team of a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. Much can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with an exceptionally talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

About You

  • PhD in organic chemistry, analytical chemistry, biophysics, biochemistry, physics, or a related field 
  • Hands-on experience in microfluidic electrophoresis device design, construction, and implementation
  • Good working knowledge of the principles of electrophoresis and microfluidics and applications in biochemistry 
  • Meticulous about documenting experimental and analytical work with remarkable attention to detail in all aspects of the job
  • Experience in other methods of analytical chemistry
  • Experience in operating and maintaining modern automation systems (liquid handlers, HPLC/LCMS, etc) 
  • Ability to translate broad directives into action with minimal supervision
  • Excellent oral and written communication skills
  • Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions in a fast-paced, goal-oriented, team environment
  • Passion for making a difference in the world

Nice to Have

  • Experience or knowledge of DNA handling techniques like PCR, restriction digestion, gel electrophoresis, cell culture, etc
  • A demonstrated expertise in scientific programming (e.g., Python, Java, C++, SVL) with practical application of these skills is a strong plus

About insitro

insitro is a data-driven drug discovery and development company using machine learning and data generation at scale to transform the way that drugs are discovered and delivered to patients. insitro’s approach focuses on the development of predictive machine learning models to be brought to bear on key bottlenecks in pharmaceutical R&D. The company has established enabling collaborations with Gilead in NASH and Bristol Myers Squibb in ALS. insitro is located in South San Francisco, CA and has been supported by top tech, biotech, and crossover investors since formation in 2018. For more information on insitro, please visit the company’s website at

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  • Location
    South San Francisco, California
  • Department
    High-Throughput Chemistry
  • Employment Type