Associate Scientist II/III, Functional Genomics

Functional Genomics · South San Francisco, California
Department Functional Genomics
Employment Type Full-Time

The Opportunity

The heart of insitro’s strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology to address key bottlenecks in the drug development pipeline. In alignment with this strategy, the Functional Genomics group is building the foundational platforms for performing high-throughput screens. As an associate scientist, you will work with a dynamic team to help develop cutting edge functional genomic screens using CRISPRn/a/i, next-generation sequencing, and image phenotyping to model human diseases and discover drugs. We are looking for motivated and talented candidates who are interested in being part of a unique, cross-disciplinary team of biologists, bioengineers, machine learners, and data scientists who want to make a difference. 

You will be joining as the founding team of a biotech startup that has long-term stability due to significant funding, yet is very much in formation providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us and help make a difference to patients! 

About You

  • B.S./M.S. in biological science with preference for genetics and/or neuroscience background, bioengineering or relevant disciplines, or equivalent experience
  • 2-3+ years of relevant research experience, in academia or industry
  • Strong experience with mammalian cell culture required. Ideally, experience with human induced pluripotent stem cell culture (iPSC)
  • Experience with lentivirus production, titer, and transduction
  • Experience with CRISPRn/i/a genetic screening is a plus
  • Experience in molecular biology, cloning, and NGS prep
  • Experience characterizing mammalian cell cultures via FACS, single cell transcriptomics, or high-content imaging
  • Excellent lab practice, organized, detail oriented, and strong communication skills
  • Ability to work independently and collaboratively as part of a dynamic team
  • Positive attitude and eager to learn

Nice to Have

  • Experience in iPSC differentiation, particularly to neural lineages
  • Experience with microscopy, including immunohistochemistry, in situ hybridization, live cell imaging, and/or high content imaging
  • Experience conducting transcriptomics assays (single cell RNA-seq a plus)
  • Familiarity with high throughput screening and assay development
  • Familiarity with automated liquid handler systems for cell culture (i.e., Bravo, Tecan, Hamilton)
  • Familiarity with data analysis in Python, R

Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Commuter benefits
  • Paid parental leave

About insitro

insitro is a data-driven drug discovery and development company using machine learning and data generation at scale to transform the way that drugs are discovered and delivered to patients. insitro’s approach focuses on the development of predictive machine learning models to be brought to bear on key bottlenecks in pharmaceutical R&D. The company has established enabling collaborations with Gilead in NASH and Bristol Myers Squibb in ALS. insitro is located in South San Francisco, CA and has been supported by top tech, biotech, and crossover investors since formation in 2018. For more information on insitro, please visit the company’s website at

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  • Location
    South San Francisco, California
  • Department
    Functional Genomics
  • Employment Type